Capella

Capella—the Online Voice of Progress in RNAi

Welcome to Capella, Alnylam’s destination for updates on our work translating the breakthrough discovery of RNA interference (RNAi) into an innovative new class of medicines. We’ve been pioneering RNAi therapeutics since 2002 and are excited to share our ongoing scientific progress.

Findings from a subgroup analysis of the KARDIA-2 Phase 2 study of zilebesiran, in development for the treatment of hypertension, and new data from post-hoc analyses of the APOLLO-B Phase 3 and APOLLO-OLE studies of patisiran in patients with ATTR amyloidosis with cardiomyopathy (ATTR-CM) were presented at the European Society of Cardiology Congress (ESC) 2024.

Saxena, et al. “Subgroup Results from KARDIA-2: Impact of Demographic and Baseline Disease Characteristics on Zilebesiran Response in Patients with Hypertension Uncontrolled by a Standard Oral Antihypertensive”

Lairez, et al. “Long-term Effects of Patisiran on Survival and Cardiac Parameters in Patients with Transthyretin-Mediated Cardiac Amyloidosis: Post-hoc Analyses of APOLLO-B and Cardiac Subpopulation of APOLLO-OLE”

Detailed results from the Phase 3 HELIOS-B study of vutrisiran, an RNAi therapeutic in development for the treatment of ATTR amyloidosis with cardiomyopathy (ATTR-CM), were presented in a Hot Line session at the European Society of Cardiology Congress (ESC) 2024 and simultaneously published in The New England Journal of Medicine.

Fontana, et al. “Primary Results from HELIOS-B, a Phase 3 Study of Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy”

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Additional interim results from the single ascending dose part of the ongoing Phase 1 study of mivelsiran (ALN-APP), an investigational RNAi therapeutic in development for Alzheimer’s disease and cerebral amyloid angiopathy, were presented at the Alzheimer’s Association International Conference (AAIC) 2024.

Cohen, et al. “Single ascending dose results from an ongoing Phase 1 study of mivelsiran (ALN-APP), the first investigational RNA interference therapeutic targeting amyloid precursor protein for Alzheimer’s disease”

Preclinical data from a Tau-targeting program were presented at the Alzheimer’s Association International Conference (AAIC) 2024. An RNAi therapeutic development candidate leveraging Alnylam’s C16-siRNA CNS delivery platform was shown to achieve durable Tau-lowering for at least four months after a single intrathecal dose with an encouraging tolerability profile.

Kevin Sloan, et al, “A New Approach to Tau Lowering Using C16-siRNA Conjugates”

Results from an analysis of 41 studies that measured the six-minute walk test (6MWT) and rates of hospitalization and/or death in people with cardiomyopathy, including transthyretin amyloidosis with cardiomyopathy, were published in the Journal of Comparative Effectiveness Research.

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We presented additional positive interim results for an ongoing Phase 1/2 study of ALN-KHK, an investigational RNAi therapeutic targeting ketohexokinase in development for the treatment of type 2 diabetes, at the American Diabetes Association’s 84th Scientific Sessions. Our investigational therapeutic showed an encouraging safety and tolerability profile and target engagement in the single ascending dose part of the study in healthy overweight to obese adults.

Maratos-Flier, et al. “ALN-KHK, an Investigational RNA Interference Therapeutic, Successfully Targets Hepatic Ketohexokinase in a Single Ascending Dose Study of Overweight to Obese Adults”

New results from the KARDIA-2 Phase 2 study of zilebesiran, an investigational RNAi therapeutic in development for the treatment of hypertension, when added to standard of care antihypertensive medications, were presented at the 33rd European Meeting on Hypertension and Cardiovascular Protection. Additional details were presented on the KARDIA-3 study design with zilebesiran as an add-on therapy in patients with high cardiovascular risk and hypertension inadequately controlled by standard of care antihypertensives.

Saxena, et al. “Zilebesiran as Add-On Therapy in Patients with Hypertension Inadequately Controlled with a Standard Antihypertensive Medication: Efficacy and Safety Results from the KARDIA-2 Study”

Havasi, et al. “Zilebesiran as Add-On Therapy in Patients with High Cardiovascular Risk and Hypertension Inadequately Controlled by Standard of Care Antihypertensive”

New results from a post hoc subgroup analysis of the ENVISION Phase 3 study evaluating long-term outcomes in patients with acute hepatic porphyria who were not attack-free after the first six months of GIVLAARI® (givosiran) treatment were presented at the European Association for the Study of the Liver (EASL) Congress 2024.

Ventura, et al. “Long-term clinical outcomes of patients with acute hepatic porphyria who were not attack-free after 6 months of givosiran treatment in a subgroup analysis of the phase 3 ENVISION study”

New 54-month results from the Phase 2 open-label extension study evaluating long-term treatment with OXLUMO® (lumasiran) in patients with primary hyperoxaluria type 1 were presented at the 61st European Renal Association (ERA) Congress.

Frishberg, et al. “Long-term Treatment with Lumasiran: Final Results from the Phase 2 Open-Label Extension Study”

A new subgroup analysis from the KARDIA-1 Phase 2 study of zilebesiran, an investigational RNAi therapeutic in development for the treatment of hypertension, was presented at the 2024 American College of Cardiology (ACC) Annual Scientific Session.

Saxena, et al. “Consistent Antihypertensive Efficacy of the RNA Interference Therapeutic Zilebesiran: Subgroup Results from the KARDIA-1 Phase 2 Study in Patients with Hypertension”