@media(max-width:1000px) {

    .h2-big.text-center {
        text-align: left !important;
    }

    .header_inner_right {
        top: -1px;
    }

    .search-filters .nav-tabs {
        margin: 30px 0 0 11px;
        display: flex;
        flex-wrap: wrap;
        justify-content: space-around;
    }

    .alnylam_search--main-wrap .search-filters .nav-tabs>li {
        margin: 0 7px;
    }

    .alnylam_search--main-wrap .search-filters ul li:first-child {
        margin-left: 0;
    }

    .alnylam_search--main-wrap .search-results__header {
        flex-wrap: wrap;
    }

    .alnylam_search--main-wrap .search-results__header p {
        padding-left: 0;
        width: 100%;
        text-align: center;
    }

    .search-filters .nav-tabs a,
    .search-filters .nav-tabs {
        margin-left: 0;
        margin-right: 0;
    }

    #search-sort {
        margin-right: 0;
        margin-left: auto;
        margin-top: 50px;
        margin-bottom: -70px;
        z-index: 9999;
        cursor: pointer;
    }

    .footer_bottom .left-footer-bottom {
        padding: 16px 0;
    }

    .footer_bottom span.copyright {
        line-height: 20px;
        max-width: 272px !important;
        text-align: center !important;
        font-weight: normal !important;
        font-size: 13px !important;
        margin: auto;
        line-height: 16px;
    }

    .footer_top_holder {
        padding: 0px 22px 8px !important;
    }

    footer .footer_inner .footer_top {
        background-repeat: repeat-x !important;
        overflow: hidden !important;
        padding-top: 40px !important;
        padding-bottom: 0 !important;
        padding-left: 0 !important;
        padding-right: 0 !important;
    }

    footer .footer_inner .footer_top_holder .footer_top .col a {
        padding-bottom: 8px !important;
    }

    .footer_top_holder .footer_top .container_inner .four_columns.clearfix {
        padding: 0 11px;
        margin-left: 0;
        margin-right: 0;
    }

    .footer_top_holder .footer_top .container_inner .four_columns.clearfix .col {
        width: 100% !important;
    }

    /*******/
    header {
        padding: 10px 9.5px 10px 12px !important;
    }

    #toggle span {
        height: 17px !important;
        margin-top: -5px;
    }

    .menu_bottom .logo_wrapper {
        padding: 0;
    }

    header .header_top {
        padding-right: 28px;
    }

    .alnylam__basic-search-block #search-open-btn {
        left: -29px;
        top: 7.5px;
    }

    .open_search .header_bottom {
        left: 0px !important;
        top: 6px;
        width: 100% !important;
    }

    .alnylam__basic-search-block .input-group {
        margin-right: 8px;
        max-width: unset !important;
    }

    .open_search .alnylam__basic-search-block .input-group input {
        max-width: 100% !important;
        border-radius: 0;
        border: 1px solid #ddd;
        width: 100%;
        height: 41px;
        padding: 9px 35px 12px 16px;
        color: #002855;
        display: block;
        box-shadow: none;
        font-size: 16px;
        font-stretch: normal;
        font-style: normal;
        line-height: normal;
        letter-spacing: normal;
        margin-left: 0;
    }

    .open_search .alnylam__basic-search-block #search-close-btn {
        margin-top: -1px;
        min-width: 24px;
        margin-right: 0;
        margin-bottom: 0 !important;
    }

    .open_search .alnylam__basic-search-block #search-close-btn {
        margin-top: -1px;
        min-width: 24px;
        margin-right: -2px;
        margin-bottom: 0 !important;
        padding-right: 0 !important;
    }

    .open_search #search-input button {
        position: absolute;
        top: 8px;
        right: 10px !important;
    }

    .open_search .header_inner_right {
        float: none;
        width: 100%;
        height: auto;
        position: relative;
        z-index: 110;
        flex: 0 0 100%;
    }

    .header_top_bottom_holder {
        max-height: 36px;
    }

    .logo_wrapper .q_logo img {
        margin-top: 1px;
    }

    .mobile-menu-container {
        padding: 4px 6.5px 16px 4px;
    }

    header:not(.sticky):not(.scrolled).mobile-menu-open .header_bottom {
        left: -18px;
        top: -4px;
    }

    .mobile-menu-open ul li #language_selector_1 {
        position: relative;
    }

    .mobile-menu-open ul li #language_selector_1::before {
        content: "";
        background: url(/sites/default/files/img/social-icons/navigation-global-caret-down.svg) no-repeat right !important;
        right: -17px !important;
        top: 2px !important;
        background-size: contain !important;
        width: 20px !important;
        height: 20px !important;
        position: absolute;
        transition: .3s all;
    }

    .mobile-menu-open ul li #language_selector_1 i {
        display: none;
    }

    nav#languages {
        position: fixed;
        left: unset;
        top: 50px;
        max-height: 426px;
        right: 12px;
        padding: 12px 11px 14px 16px;
        z-index: 9999;
        width: 245px;
        height: 426px;
        background: #fff;
        overflow-y: scroll;
    }

    .mobile-menu-open ul li #language_selector_1.opened::after {
        content: "";
        top: unset;
        right: 4.5px;
        background: #fff;
        width: 12px;
        height: 10px;
        position: absolute;
        transform: rotate(-315deg);
        bottom: -17.4px;
    }

    #languages .row1 {
        height: auto;
        font-size: 16px;
        width: auto;
        float: none;
        padding-bottom: 8px;
        border-bottom: 1px solid #999999;
        margin-bottom: 7px;
        margin-right: 0;
        margin-top: -2px;
    }

    nav#languages li {
        padding: 7px 0 !important;
    }

    header ul li #languages .link-text a {
        line-height: 24px !important;
    }

    header #menu-main-menu-1 li span {
        padding-left: 0 !important;
        font-stretch: normal;
        font-style: normal;
        letter-spacing: normal;
        font-size: 20px;
        font-weight: normal !important;
        line-height: 32px !important;
        display: block !important;
        height: auto !important;
    }

    #menu-main-menu-1>li:nth-child(1)::after {
        margin-bottom: 5px;
    }

    .flow-icon {
        max-width: 28px;
    }

    header .drop_down #menu-main-menu-1 .second.drop_down_start span {
        padding-left: 0 !important;
        display: block !important;
        height: auto !important;
        border-left-width: 2px;
        font-size: 14px !important;
        font-weight: 600 !important;
        font-stretch: normal !important;
        line-height: 24px !important;
        letter-spacing: normal !important;
    }

    .drop_down #menu-main-menu-1 .second.drop_down_start {
        margin-top: 0 !important;
    }
}

@media(min-width:768px) and (max-width:991px) {
    .flow-us .flow-icon:nth-child(2) img {
        width: 26px;
    }
}

@media (max-width:400px) {
    .alnylam_search--main-wrap form .searchbar input {
        max-width: 58%;
    }
}

@media only screen and (min-width: 768px) and (max-width: 850px) {
    .view-banner-slideshow .owl-theme .owl-buttons {
        bottom: 25px !important;
    }

    .view-banner-slideshow .owl-pagination {
        bottom: 20px !important;
    }
}

@media (max-width: 1000px) {
    .page_header {
        z-index: 99999999 !important;
    }

    h1,
    h2,
    h3,
    h4,
    h5,
    h6 {
        color: #003366;
    }

    h1 {
        font-size: 32px;
        font-weight: 700;
        line-height: 32px;
    }

    /* h2 {
      font-size: 28px !important;
      line-height: 32px !important;
      font-weight: 300 !important;
      text-align: left !important;
    } */
    .light-blue .inner-bg-light-blue.text-center h2 {
        text-align: left !important;
    }

    h1+h2 {
        margin-bottom: 16px !important;
    }

    p+h2:not(.section-header) {
        margin-bottom: 24px !important;
    }

    a.our-company.bullet-point:before,
    a.our-science.bullet-point:before,
    a.our-products.bullet-point:before,
    a.our-news.bullet-point:before {
        top: 14px !important;
        left: 12px !important;
    }

    .news .row {
        padding-left: 0;
    }

    h2.our-company,
    h2.our-science,
    h2.our-news,
    h2.our-product,
    h2.secondary-dark,
    h2.secondary-light {
        font-size: 32px !important;
        font-weight: 700 !important;
        line-height: 32px !important;
    }

    p.mobile-eyebrow {
        display: block !important;
        margin-top: -25px !important;
        margin-bottom: 16px;
    }


    .alnylam__basic-search-block.open {
        z-index: 99;
        position: relative;
    }

    /* OUR-COMPANY */
    h1.our-company::before,
    .second-title.our-company::before {
        background-image: url(/sites/default/files/img/lines-mobile-our-company.svg);
        background-size: cover;
        width: 14px;
        height: 21px;
        margin-right: 9px;
        margin-left: -23px !important;
        position: unset;
    }

    .dark-button-more {
        width: 100%;
        text-align: center;
        padding: 15px 0px !important;
    }


    .hide_mobile {
        display: none !important;
    }



    /*header css*/
    header {
        padding-left: 0px;
        padding-right: 0px;
    }

    .header-top-middle {
        display: none;
    }

    .header-bottom-left a#superfish-main-toggle span {
        width: 24px;
        display: block;
        top: -35px;
        font-size: 0px;
        background: url(/sites/default/files/img/group-5.svg) no-repeat;
        overflow: hidden;
        position: absolute;
        height: 20px;
        left: 10px;
    }

    .search-language-block .header-bottom-left .block-superfish {
        position: absolute;
        left: 0;
        height: 100vh;
        top: 0;
        background: #001f3d;
        z-index: 1;
        padding-top: 16px;
    }

    header ul li span{
        font-size: 16px;
        color: #fff;
    }

  

    .search-language-block .header-bottom-left a#superfish-main-toggle span {
        background: url(/sites/default/files/img/buttons-close-x-48-px.png);
    }

    .search-language-block header {
        background: #001f3d;
    }

    .search-language-block .header-bottom-right .header-right-search {
        display: none;
    }



    .header-bottom-right .header-right-search,
    body.search-open .header-bottom-right .header-right-search {
        background: url(/sites/default/files/img/search.png) no-repeat;
        background-size: cover;
        width: 24px;
        height: 24px;
        float: right;
        margin-top: -31px;
    }

    .heading-image-popup-content-area.col-sm-4 {
        margin-top: 0px !important;
    }



    #block-views-block-banner-slideshow-block-1 .owl-item .field-content .description img {
        height: auto !important;
    }

    .view-banner-slideshow .owl-theme .owl-controls .owl-buttons div.owl-prev {
        margin: 0 0px 0 0;
        width: 40px;
        height: 40px;
    }

    .view-banner-slideshow .owl-theme .owl-buttons {
        top: auto;
        bottom: 32px;
        width: 90%;
        justify-content: space-between;
    }

    .view-banner-slideshow .owl-pagination {
        text-align: center;
        bottom: 32px;
        z-index: 9999;
    }

    .service-content-area .service-field-area .service-box {
        display: unset !important;
    }

    /* ----------------------------------------------------------- */
    .font-20 {
        font-size: 20px !important;
        line-height: 1.6 !important;
    }


    .button-more {
        padding: 15px 0px !important;
        width: 100% !important;
        margin: 32px auto auto auto !important;
        text-align: center;
    }





    a.button-more {
        color: #00245b !important;
        border-bottom: 4px solid #b1d9f3 !important;
        width: 100%;
    }

    /* -----featured article------ */
    .description--component {
        width: 100% !important;
        margin: auto !important;
        padding: 0 32px;
    }


    /* .footer-top .footer-top-column-2, .footer-top-column-3, .footer-top-column-4 {
         display: none;
    }
     */
    nav#block-footerfirst {
        display: none;
    }


    #block-footermenu {
        display: block;
    }


    .footer-bottom .footer-bottom-right-area.col-sm-6 {
        display: none;
    }

    .footer-bottom .footer-bottom-left-area.col-sm-6 {
        width: 100%;
    }

    .footer-bottom-left-area p {
        max-width: 255px;
        margin: auto;
    }

    /* features articles */
    h1.our-news::before {
        background-image: url(/sites/default/files/img/lines-mobile-our-news.svg);
        background-size: cover;
        width: 14px;
        height: 21px;
        margin-right: 9px;
    }

    .news .row,
    .news span {
        display: block !important;
    }

    .paragraph--type--add-block .addblock--component {
        width: 100% !important;
    }

    .view-news .slick-initialized .slide .slide__content {
        padding-bottom: 200px;
        margin: auto;
        max-width: 375px;
    }

    .view-news .slick-initialized .slide .slide__content {
        padding-bottom: 0;
        margin: auto;
        max-width: 375px;
        padding-left: 16px;
        padding-right: 16px;
    }

    .view-news .slick-list.draggable {
        padding: 0 55px !important;
    }

    /* image */
    .view-news .media.media--ratio {
        height: 194px;
    }

    .view-news .slick-slide .slide__media img {
        width: 100% !important;
        left: 7px !important;
        margin: 0px !important;
    }

    /* image */
    .view-news .slide__caption {
        width: 100% !important;
    }

    .view-news .slick-slide .slide__caption .slide__description {
        top: -29px !important;
        left: 7px !important;
        margin: 0 !important;
    }

    .view-news .slick__arrow {
        top: 99%;
        left: -126px;
    }

    .view-news .slick-dots li {
        margin: 0 14px;
    }

    .view-news .slick-dots li button:before {
        top: 29px;
        right: 0;
        left: 30px;
        width: 50px;
        height: 2px;
        background: #d8d8d8;
    }


    .about-alnylam .col-sm-12 {
        padding: 0 15px;
    }

    #dark-bg-banner {
        width: 100% !important;
    }

    .trials .three-column-card-box .button-more {
        position: unset !important;
    }

    #simple-banner-wrapper .quote {
        width: 100% !important;
    }

    .trials .icon-copy-link-list>div {
        width: calc(100% - 32px) !important;
    }

    .icon-copy-link-list-feilds .row .col-sm-3,
    .icon-copy-link-list-feilds .row .col-sm-9 {
        width: 100%;
    }

    .service-content-area .service-field-area .service-image-field {
        width: 100%;
    }

    .accordion-column-fields .inner-block-1 div.order-test-button {
        width: auto;
    }

    .whole-callout-h1-cta--component.capella-node {
        margin: 50px -50px 0 -50px;
        padding: 64px 50px !important;
    }

    .callout-h1-cta--component>div {
        width: 100% !important;
    }

    .icon-copy-link-list-feilds .row .col-sm-3,
    .icon-copy-link-list-feilds .row .col-sm-9 {
        width: 100%;
        padding-left: 0;
        padding-right: 0;
    }

    .heading-image-popup-content-area.col-sm-4 .image-field img {
        width: 100%;
    }

}


@media only screen and (min-width: 1000px) {
    .hide_desktop {
        display: none !important;
    }
}


@media(max-width:1000px) {
    .alnylam__basic-search-block .search-close-btn {
        margin-left: 0;
        margin-bottom: 0;
    }

    li.facebook a {
        background-image: url("/themes/custom/alnylam/images/social-icons/facebook.svg");
    }

    .search-close-btn img {
        width: 24px;
        max-width: none;
        padding-right: 3px;
        margin-bottom: 4px;
    }

    .search-language-block .mobile-header-search .language {
        width: 24px;
        height: 24px;
        margin-right: 3.5px;
    }

    h2.featured-articles-heading {
        text-align: center;
    }
}


@media (min-width:768px) {
    p.mobile-eyebrow {
        display: none !important;
    }
}
@media(max-width:767px) {
    .alnylam__basic-search-block #search-open-btn {
        left: -10px;
        top: 7.5px;
    }
}