New analyses highlight that vutrisiran improved measures of heart structure and function and reduced amyloid burden in some patients.

Further findings show vutrisiran preserved kidney function and reduced the risk of death and cardiovascular (CV) events in patients with advanced chronic kidney disease (CKD).

Results from Cohort B of the KARDIA-3 Phase 2 trial evaluating zilebesiran in patients with uncontrolled hypertension with established or at high risk for CV disease on two or more background medications were also presented as a late-breaking abstract.

Fontana, et al. “Effects of Vutrisiran on Measures of Cardiac Structure, Function and Amyloid Burden by Cardiovascular Magnetic Resonance from the HELIOS-B Trial”

Jering, et al. “Left Atrial Strain and Clinical Outcomes in Transthyretin Amyloid Cardiomyopathy: Insights from the HELIOS-B Trial on Vutrisiran Efficacy”

Manafi, et al. “Right Ventricular Free Wall Strain and Clinical Outcomes in Transthyretin Amyloid Cardiomyopathy and Effect of Vutrisiran: The HELIOS-B Study”

Sheikh, et al. “Vutrisiran Improved Outcomes Versus Placebo in Patients with Transthyretin Amyloidosis with Cardiomyopathy and Severe Chronic Kidney Disease: Post Hoc Analysis of HELIOS-B”

Pagidipati, et al. “KARDIA-3: A Randomized Trial of Zilebesiran Versus Placebo on Top of Standard Care for Patients with Hypertension and Established Cardiovascular Disease or High Cardiovascular Risk with or Without Chronic Kidney Disease”